Investigations on the Chromatographic Behavior of Carboxylic Acids on Silica-Based Cation Exchangers
作者:
ChristianW. Klampfl,
Wolfgang Buchberger,
Guenter Rieder,
Ian Chappell,
期刊:
Journal of Liquid Chromatography & Related Technologies
(Taylor Available online 1998)
卷期:
Volume 21,
issue 13
页码: 2069-2079
ISSN:1082-6076
年代: 1998
DOI:10.1080/10826079808006606
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Aliphatic mono and dicarboxylic acids have been separated on silica-based ion-exchangers under conditions commonly used in ion-exclusion chromatography. Various retention mechanisms including ion-exclusion, hydrophobic interaction, and adsorption are involved in the separation of these analytes. The contribution of each of these mechanisms can be manipulated by varying the characteristics of the chromatographic support like exchange capacity or type of the spacer molecule used for the binding of the sulfonate groups to the silica. Thereby, fine-tuning of the separation selectivity is possible.
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