AbstractAlprenolol was given to 26 women, participants in a population study, who were found to have arterial hypertension. These women were followed up for about two years, during which period they received β‐adrenergic blocking agents. Except for 6 weeks on placebo and 8 weeks on propranolol, alprenolol was given during the period. Those who had an initial effect from alprenolol also had long‐term benefit of the substance. Blood pressure seemed to remain at the same level during a follow‐up period of two years. Except for one woman who at the end of the two‐year period had slight obstructive bronchial symptoms, which may have been caused by alprenolol, no adverse reactions were seen. After an initial rise when starting treatment with alprenolol serum uric acid values were subsequently normalized and after a two‐year period they seemed to be even lower than the pre‐trea