Coexistence of Multiple Monoclonal Immunoglobulins with Identical Constant Regions in One Patient
作者:
An-Chuan Wang,
Hugh Fudenberg,
Roger Creyssel,
期刊:
Acta Haematologica
(Karger Available online 1982)
卷期:
Volume 68,
issue 3
页码: 187-195
ISSN:0001-5792
年代: 1982
DOI:10.1159/000206981
出版商: S. Karger AG
关键词: Monoclonal immunoglobulins;Constant region;Variable region;Multiple myeloma;Amino acid sequence;B cells
数据来源: Karger
摘要:
Two populations of IgG molecules, designated F-IgG3(χ) and S-IgG3(χ), were isolated from a patient with multiple myeloma. The constant regions of the two molecules appear to be identical, since the heavy chains of both belong to the γ3 subclass and both molecules are positive for G3m(5), G3m(10), and G3m(ll) but negative for G3m(21), Km(l) and Km(2) allotypes. In contrast, the two molecules have different variable regions, since (a) they do not share idiotypic determinant(s); (b) their light chains have different NH2 terminal amino acid sequences, and (c) both their heavy and light chains have different peptide maps and amino acid compositions. SDS-polyacrylamide gel electrophoresis showed that the F-IgG3(χ) molecules have two kinds of light chains. One, designated χn, has a normal molecular weight (approximately 23,000); the other, designated χh, has a molecular weight of approximately 2
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