Tiapride: Effects on Tardive Dyskinesia and on Prolactin Plasma Concentrations
作者:
W. Greil,
S. Auberger,
H. Haag,
E. Rüther,
期刊:
Neuropsychobiology
(Karger Available online 1985)
卷期:
Volume 14,
issue 1
页码: 17-22
ISSN:0302-282X
年代: 1985
DOI:10.1159/000118195
出版商: S. Karger AG
关键词: Tiapride;Dyskinesia;drug-induced;Prolactin;Tranquilizing agents;major;Antiparkinson agents;Schizophrenia;Receptors;dopamine;Tardive dyskinesia
数据来源: Karger
摘要:
In a placebo-controlled double-blind crossover study of 21 patients chronically treated with neuroleptics and suffering from tardive dyskinesia, tiapride (600 mg/day, mean plasma level: 682 ng/ml) exhibited a transient efficacy during 12 weeks of treatment, most distinct in the 6th week (p < 0.01). Tiapride induced an increase of prolactin plasma levels, on the average, from 1,195 to 2,179 µlU/ml (p < 0.01). Tiapride was well tolerated. Increase of parkinsonism was only mild and not significant. The results underline the difficulty in treating tardive dyskinesia and, thus, confirm the importance of prevention
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