In vivoPercutaneous Penetration of Corticoids in Man and Unresolved Problems in Their Efficacy
作者:
Howard I. Maibach,
期刊:
Dermatology
(Karger Available online 1976)
卷期:
Volume 152,
issue 1
页码: 11-25
ISSN:1018-8665
年代: 1976
DOI:10.1159/000257863
出版商: S. Karger AG
关键词: Hydrocortisone;Vehicles;Pharmacokinetics;Percutaneous penetrationin vivo;Corticosteroids
数据来源: Karger
摘要:
This paper reviews the percutaneous penetration of corticosteroids in vivo in man utilizing urinary excretion of 14C-hydrocortisone as the experimental method. In general corticosteroids are only minimally absorbed from most areas of glabrous skin. Increasing the amount that penetrates – by use of occlusion – and increasing concentration provides the most practical method currently available for increasing efficacy in treatment-resistant dermatoses. Some practical research problems relevant to topical corticoid efficacy are discus
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