The structural and functional interrelationships of muscarinic acetylcholine receptor subtypes
作者:
J. Ramachandran,
E. G. Peralta,
A. Ashkenazi,
J. W. Winslow,
D. J. Capon,
期刊:
BioEssays
(WILEY Available online 1989)
卷期:
Volume 10,
issue 2‐3
页码: 54-57
ISSN:0265-9247
年代: 1989
DOI:10.1002/bies.950100205
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractMolecular cloning of the genes encoding the muscarinic acetylcholine receptors has shwon that receptor subtypes classified on the basis of pharmacological properties are related polypeptides encoded by distinct genes. These studies have laso revealed the existence of novel muscarinic receptor subtypes. Functional analysis of each of the subtypes expressed in mammalian cells indicates that the different subtypes activate distinct biochemical pathways, a finding that explains the tissue‐specific physiological response elicited by the neurotransmitter, acetylcholin
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