Facial eczema in goats: The toxicity of sporidesmin in goats and its pathology
作者:
B.L. Smith,
P.P. Embling,
期刊:
New Zealand Veterinary Journal
(Taylor Available online 1991)
卷期:
Volume 39,
issue 1
页码: 18-22
ISSN:0048-0169
年代: 1991
DOI:10.1080/00480169.1991.35650
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Groups of six goats were orally dosed with sporidesmin at rates of 0.3, 0.6, 1.2 and 2.4 mg of sporidesmin per kg body weight and their responses up to 6 weeks later compared with those of sheep dosed at the same time. Clinical facial eczema and pathological lesions similar to those found in sheep were found in all the goat breeds, but at higher dose rates of sporidesmin than those which caused equivalent lesions in sheep. Saanens were the most susceptible goat breed, requiring 2–4 times as much sporidesmin as sheep to achieve similar effects. G4 and feral goats required 4–8 times the sheep dose of sporidesmin to obtain similar responses. Gamma-glutamyl-transferase reached its highest serum levels after 20 days while glutamate dehydrogenase and aspartate aminotransferase reached their highest levels between 10 and 20 days. Alkaline phosphatase did not rise consistently to high levels in affected goats.
点击下载:
PDF (4809KB)
返 回