Carcinoma‐in‐situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytoma
作者:
N. E. SKAKKEBÆK,
J. G. BERTHELSEN,
A. GIWERCMAN,
J. MÜLLER,
期刊:
International Journal of Andrology
(WILEY Available online 1987)
卷期:
Volume 10,
issue 1
页码: 19-28
ISSN:0105-6263
年代: 1987
DOI:10.1111/j.1365-2605.1987.tb00161.x
出版商: Blackwell Publishing Ltd
关键词: Carcinoma‐in‐situ testis;gonocytes;seminoma;nonseminoma;spermatocytoma;spermatocytic seminoma;histogenesis
数据来源: WILEY
摘要:
Based on evidence from morphological and histochemical studies and from clinical experience, the following hypotheses are proposed: (1) carcinoma‐in‐situ (CIS) germ cells are malignant gonocytes; (2) these CIS gonocytes have some capacity to regress into more primitive, totipotent embryonic cells which can give rise to all types of nonseminomatous germ cell tumours; (3) the tumour germ cells of classical seminomas are malignant gonocytes derived from CIS gonocytes which have lost their ability to regress into totipotent embryonic cells; (4) the ability of CIS gonocytes to regress into totipotent embryonic cells decreases with age, whereas the capacity to form classical seminoma cells is preserved; (5) the transformation of CIS gonocytes into invasive tumours is dependent on factors such as gonadotrophins and/or testicular steroids; (6) the pathogenesis of classical and spermatocytic seminoma are unrelated.As a consequence of these hypotheses an alternative nomenclature for carcinoma‐in‐situ, seminoma and dysgerminoma is su
点击下载:
PDF
(3608KB)
返 回