Prothrombin Complex Concentrates for Clinical Use1
作者:
S. Chandra,
H.G.J. Brummelhuis,
期刊:
Vox Sanguinis
(WILEY Available online 1981)
卷期:
Volume 41,
issue 5‐6
页码: 257-273
ISSN:0042-9007
年代: 1981
DOI:10.1111/j.1423-0410.1981.tb01048.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
AbstractProthrombin complex concentrates prepared for clinical use are reviewed with emphasis on frequently observed adverse reactions such as viral hepatitis and thromboembolic complications. Preparation procedures and quality control are described briefly, and the use of these concentrates in the treatment of hemophilia A patients who develop factor VIII inhibitors is also described. The causes of and methods for the detection of potential thrombogenicity are discussed and suggestions which may result in a safer product are made.
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