Idiopathic Orthostatic Hypotension
作者:
R. Schober,
J.W. Langston,
L.S. Forno,
期刊:
European Neurology
(Karger Available online 1975)
卷期:
Volume 13,
issue 3
页码: 177-188
ISSN:0014-3022
年代: 1975
DOI:10.1159/000114674
出版商: S. Karger AG
关键词: Orthostatic hypotension;Postural hypotension;Lewy body parkinsonism;Striato-nigral degeneration;CSF monoamines
数据来源: Karger
摘要:
Two cases of idiopathic orthostatic hypotension are reported, one associated with striato-nigral degeneration (case 1) and the other with Lewy body parkinsonism (case 2). In case 1, cerebrospinal fluid monoamine studies were carried out before and during treatment with 5-HTP and L-dopa. Low values of 5-HIAA appeared to be associated with degeneration of the spinal cord intermedi-olateral column. L-dopa had a beneficial effect on both parkinsonism and hypotension over a period of 6 months. New pathologic observations included changes in the sacral cord and a topographically related involvement of the substantia nigra and striatum, consistent with recent experimental neuroanatomical data.
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