Caring for the self ns an entrepreneur requires courage, commitment, and persistence in self-care activities. Utilizing her 23 years of experience and input from other nurse entrepreneurs, this author discusses the 19 principles she sees as necessary to maintain health. The principles outlined in this article are considered the basics for survival, as well as necessary for personal and professional growth of a nurse entrepreneur. Each is accompanied by key issues to be considered or specific suggestions for improvement in physical, emotional, and spiritual health.