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Massive Systemic Amyloidosis Associated with Light-Chain Deposition Disease

 

作者: X. Troussard,   B. Hurault de Ligny,   B. Gallet,   D. Ganeval,   J.-C. Mandard,   J.-P. Ryckelynck,   M. Leporrier,  

 

期刊: Nephron  （Karger Available online 1989）
卷期: Volume 52, issue 2  

页码: 139-143

 

ISSN:1660-8151

 

年代: 1989

 

DOI:10.1159/000185616

 

出版商: S. Karger AG

 

关键词: Light-chain deposition disease;Systemic AL amyloidosis;Multiple myeloma

 

数据来源: Karger

 

摘要:

A 72-year-old woman presented with rapidly progressive renal failure and multiple myeloma. The patient died 6 months later of severe hepatic insufficiency. The light-microscopic, immunological and ultrastructural findings showed widespread kappa-light-chain deposits including the kidneys, liver, spleen, heart, lungs, tongue, ovary, pancreas and bone marrow associated with massive AL amyloid deposits in the same organs and in the thyroid gland. The concurrent presence of two different deposits is very unusual and the possible mechanisms for such an association are discussed.

 

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