Serum Lipids, Lipoproteins and Apolipoproteins in Children With and Without Familial History of Premature Coronary Heart Disease
作者:
WidhalmK.,
KochS.,
PakostaR.,
SchurzM.,
BrendingerM.,
期刊:
Journal of the American College of Nutrition
(Taylor Available online 1992)
卷期:
Volume 11,
issue sup1
页码: 32-35
ISSN:0731-5724
年代: 1992
DOI:10.1080/07315724.1992.10737981
出版商: Routledge
关键词: lipoproteins;apolipoproteins;children;familial premature coronary heart disease
数据来源: Taylor
摘要:
A positive family history of premature cardiovascular disease is recognized as an independent predictor of risk for cardiovascular death in first degree relatives. It is of great interest whether the progeny of families with manifest coronary heart disease can be discriminated from children with a negative family history. Therefore, we examined serum lipids, lipo- and apolipoproteins in 338 offspring whose fathers and/or mothers had been affected with a myocardial infarction before the age of 55, in comparison with 448 age- and sex-matched, healthy controls. Statistical analyses revealed marked differences between the two groups: In both age groups only high-density lipoprotein cholesterol (HDL-C), as a single parameter, and the ratios of total cholesterol (TC)/HDL-C, as well as low-density lipoprotein cholesterol (LDL-C)/HDL-C, showed a significant difference between the risk and nonrisk groups. Whereas the ratio of apolipoprotein A1 (ApoAI) to apolipoprotein B is the strongest discriminator in children≤20 years, the ratio of HDL-C/ApoAI takes this position in the older ones. Apolipoproteins seem to be of considerable importance as risk indicators between offspring who might be at higher risk for later cardiovascular diseases, even in childhood and younger adolescence.
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