Effects of Indeloxazine, (+)-2-[Inden-7-yloxy)methyl]morpholine Hydrochloride on Cerebrospinal Fluid Monoamine Metabolites
作者:
Yoshikuni Mizuno,
Takashi Shimabukuro,
Nobuo Fukuzawa,
期刊:
European Neurology
(Karger Available online 1988)
卷期:
Volume 28,
issue 2
页码: 84-86
ISSN:0014-3022
年代: 1988
DOI:10.1159/000116236
出版商: S. Karger AG
关键词: Indeloxazine;Homovanillic acid;5-Hydroxyindoleacetic acid;Methoxyhydroxyphenylen glycol;Dopamine;Cerebrospinal fluid;Dementia;treatment of
数据来源: Karger
摘要:
Effects of indeloxazine, a new compound which has been thought to block reuptake of serotonin and noradrenaline, on cerebrospinal fluid monoamine metabolites were evaluated in 11 patients with dementia. Treatment with 90 mg/day of indeloxazine for 6–8 weeks resulted in significant reduction in methoxyhydroxyphenylen glycol and 5-hydroxyindoleacetic acid in these patients. These findings are consistent with results reported in experimental animals. The mode of action with respect to changes in monoamine metabolites and therapeutic implications of this compound are discusse
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