Tumor‐directed immunity in human neuroblastoma
作者:
Lindsay Morrison,
A. Cochran,
Gillian Baird,
Ann Campbell,
M. Willoughby,
期刊:
American Journal of Pediatric Hematology/Oncology
(OVID Available online 1982)
卷期:
Volume 4,
issue 1
页码: 3-10
ISSN:0192-8562
年代: 1982
出版商: OVID
数据来源: OVID
摘要:
Tumor-directed immunity was assessed in 29 patients with neuroblastoma (NB). Cell-mediated and humoral immunity were assessed in vitro using the one-stage direct capillary leukocyte migration inhibition test and the indirect, membrane immunofluorescence test, respectively. Leukocytes from 83% of NB patients, 40% of normal children, and 24% of adults were inhibited by NB-derived materials. NB patients' leukocytes reacted as frequently with materials from allogeneic neuroblastomas as with autologous extracts. Sera from 50% of N B patients, 8% of child controls, and 18% of adult controls reacted with allogeneic tissue cultured neuroblastoma cells.Leukocytes from NB patients, control children, and control adults were inhibited at a similar low frequency by extracts of human melanomas and cancers of cervix, colon, and breast. Sera from NB patients and controls reacted infrequently with cultured melanoma cells.
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