SummaryLorazepam has been used during the past two years to treat approximately 250 hospital patients suffering from symptoms of anxiety and tension. In-patients and outpatients of all ages have been treated. The average dosage range was 0.5 to 5 mg. lorazepam t.d.s. The highest daily dose was 30 mg.; the longest duration of treatment almost 2 years. Distinct improvement in symptoms such as anxiety, restlessness, agitation, tension, irritability and insomnia has been noted in about 70% of patients with very few side-effects. Typical case histories are discussed. It is concluded that lorazepam is an effective, extremely well-tolerated drug, particularly suitable for out-patients provided the dosage is carefully adjusted.