Effects of Sodium Iodate on Experimental Subretinal Neovascularization in the Primate
作者:
Tetsuya Nishimura,
Zhi-Ren Zhu,
Stephen J. Ryan,
期刊:
Ophthalmologica
(Karger Available online 1990)
卷期:
Volume 200,
issue 1
页码: 28-38
ISSN:0030-3755
年代: 1990
DOI:10.1159/000310074
出版商: S. Karger AG
关键词: Primate;Retina;Subretinal neovascularization;Retinal pigment epithelium
数据来源: Karger
摘要:
We investigated the role of the retinal pigment epithelium (RPE) in the development of subretinal neovascularization (SRN) induced by bilateral laser photocoagulation of the retinas in monkeys. RPE function was affected by a unilateral carotid injection of sodium iodate, a selective RPE toxin, before laser photocoagulation. This caused severe RPE damage in the ipsilateral eye, but did not affect the contralateral eye. After laser photocoagulation no SRN was demonstrable clinically or histopathologically in the ipsilateral eye; in contrast, active SRN showing extensive fluorescein leakage was found in the contralateral eye. These results suggest that RPE may play a role in the development of laser-induced SRN.
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