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Technological Advances in Blood Rheology

 

作者: StuartJohn,   NashGerard B.,  

 

期刊: Critical Reviews in Clinical Laboratory Sciences  (Taylor Available online 1990)
卷期: Volume 28, issue 1  

页码: 61-93

 

ISSN:1040-8363

 

年代: 1990

 

DOI:10.3109/10408369009105898

 

出版商: Taylor&Francis

 

关键词: blood rheology;erythrocyte;acute-phase response;sickle-cell anemia;and white blood cells

 

数据来源: Taylor

 

摘要:

AbstractThe science of blood rheology (study of the flow and deformability of blood) is of increasing practical importance to the investigation of blood disorders. In diagnostic laboratories, rheological tests such as the erythrocyte sedimentation rate, zeta sedimentation ratio, and plasma viscosity are used to monitor patients with an acute-phase response of>24 h duration. In sickle-cell anemia, new methods for measuring erythrocyte deformability can be used to investigate the pathogenesis of vaso-occlusion, to test potential anti-sickling drugs, and to monitor drug efficacy in clinical trials. Genetic defects in the structure of the red cell membrane can have rheological consequences, monitoring of which may be useful for diagnosis. Rheological analysis of red cells infected byPlasmodium falciparumhas indicated that their abnormal flow behavior may be an important pathological factor in malaria. Finally, the flow behavior of white blood cells, particularly neutrophils, is also important, as these cells, once activated, have the potential to occlude microvessels. The authors have reviewed the laboratory methodology and clinical applications that have led to recent advances in these aspects of blood rheology.

 

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