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Mechanisms underlying the suppression of erythropoiesis by hyperoxia

 

作者: STEPHEN KAPLAN,   SAM PILIERO,   ALBERT GORDON,   RICHARD MEAGHER,  

 

期刊: The American Journal of the Medical Sciences  (OVID Available online 1977)
卷期: Volume 273, issue 1  

页码: 71-78

 

ISSN:0002-9629

 

年代: 1977

 

出版商: OVID

 

关键词: Cobaltous chloride;Erythropoietin;Erythrogenin

 

数据来源: OVID

 

摘要:

AbstractThe possible mechanisms underlying the suppression of erythropoiesis in hyperoxic animals were studied. Male Long-Evans rats were injected with cobaltous chloride hexahydrate, a known erythropoietic stimulant. One group was exposed to a hyperoxic environment for ten hours. Both serum levels of erythropoietin (Ep) and renal levels of erythrogenin were significantly lower (p< 0.005) in the hyperoxic animals compared to those left at room air. In addition, inhibitors to Ep or erythrogenin could not be detected in either the serum or renal tissue of the hyperoxic rats. These results indicate that the primary factor responsible for the erythropoietic suppression observed in a hyperoxic environment is a decreased production of erythrogenin which results in turn, in a lowered level of circulating Ep.

 

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