Changes in the ratio of urinary α1‐microglobulin to ulinastatin levels in patients with Alzheimer‐type dementia and vascular dementia
作者:
TAKUJI INAGAKI,
TADAHIRO SHIKIMI,
HIROSHI ISHINO,
HIDEKI OKUNISHI,
SHUJI TAKAORI,
期刊:
Psychiatry and Clinical Neurosciences
(WILEY Available online 1995)
卷期:
Volume 49,
issue 5‐6
页码: 287-290
ISSN:1323-1316
年代: 1995
DOI:10.1111/j.1440-1819.1995.tb01903.x
出版商: Blackwell Publishing Ltd
关键词: trypsin inhibitor;urine.
数据来源: WILEY
摘要:
AbstractRelationships between urinary levels of α1‐microglobulin (α1M) and ulinastatin (UT) in patients with dementia were investigated. There were no significant differences in α1M and UT levels and α1M: UT ratios among three groups: age‐matched control subjects, patients with either Alzheimer‐type senile dementia (ATD) or vascular dementia (VD). Although a positive correlation was established between α1M and UT levels in these groups, the regression of the demented patients differed significantly from that of controls (P<0.05). A tendency towards a negative correlation between α1M: UT ratios and the levels of severity or duration of the disease was displayed in the ATD group, whereas a tendency toward a positive correlation between α1M: UT ratios and the levels of severity was observed in the VD group. These results suggest that changes in the relationships between urinary levels of α1M and UT may provide a useful biochemical index for diagnoses
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