Non-Parallel Response of Amylase and Chymotrypsinogen Biosynthesis following Pancreatic Stimulation: a Possible Explanation for Observed Non-Parallelism in Pancreatic Secretion
作者:
J.C. Dagorn,
D. Paradis,
J. Morisset,
期刊:
Digestion
(Karger Available online 1977)
卷期:
Volume 15,
issue 2
页码: 110-120
ISSN:0012-2823
年代: 1977
DOI:10.1159/000197992
出版商: S. Karger AG
关键词: Amylase;Chymotrypsin;DNA;Oleic acid;Pancreas;Pancreatic secretion;Rats
数据来源: Karger
摘要:
The responses of amylase and chymotrypsinogen to a pancreatic secretory stimulation (intragastric administration of oleic acid or sodium oleate) are compared in rats. This comparison concerned the rates of biosynthesis of the two enzymes, their intrapancreatic levels of storage and their rates of excretion in the juice. In each of these 3 steps, it was found that the stimulation induced non-parallel courses of amylase and chymotrypsinogen. The non-parallelism in the rates of biosynthesis was found unable to explain the entire non-parallelism observed in the rates of excretion. These results suggest that the mechanism which controls the proportions of the different enzymes in the juice is different from that which monitors the rates of individual enzymes biosynthesis.
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