Determination of the Enantiomeric Composition of a Novel Topically Active Carbonic Anhydrase Inhibitor by HPLC
作者:
T.J. Novak,
L. Berwick,
期刊:
Journal of Liquid Chromatography & Related Technologies
(Taylor Available online 1998)
卷期:
Volume 21,
issue 12
页码: 1883-1896
ISSN:1082-6076
年代: 1998
DOI:10.1080/10826079808005899
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
An HPLC method for the determination of the SS/RR stereoisomeric content of dorzolamide drug substance is described. The method employs precolumn derivatization with the chiral reagent (S)-phenethylisocyanate resulting in diastereomeric derivatives. The derivatives are separated under normal phase conditions employing a silica column. Low level detection (0.1%) of the minor RR enantiomer is achieved.
点击下载:
PDF (543KB)
返 回