Classification of Psychotropic Drugs by Rat EEG Analysis: The Anxiolytic Profile in Comparison to the Antidepressant and Neuroleptic Profile
作者:
F.N.C.M. Krijzer,
R. van der Molen,
期刊:
Neuropsychobiology
(Karger Available online 1987)
卷期:
Volume 18,
issue 1
页码: 51-56
ISSN:0302-282X
年代: 1987
DOI:10.1159/000118392
出版商: S. Karger AG
关键词: Rat;EEG analysis;Drug profile;Antidepressant profile;Neuroleptic profile;Anxiolytic profile
数据来源: Karger
摘要:
Electroencephalograms were recorded from the parietal and frontal cortex of freely moving rats held in constant vigilance by placing them in a slowly turning drum. The effects of 5 clinically effective anxiolytics, buspirone, meprobamate, phenobarbital, chlordiazepoxide and diazepam, were studied after intraperitoneal injection of different doses. After on-line fast Fourier transformation of the EEG signal, the drug effects were quantified by an Analysis of Variance. This resulted in a t profile for each drug dosage. Averaging the t profiles of all dosages of a drug results in a ‘drug profile’. Averaging the drug profiles of the 5 anxiolytic drugs tested results in an ‘anxiolytic profile’. This profile is characterized by a power decrease from 8 to 11 Hz and above 70 Hz and a power increase from 20 to 60 Hz. The anxiolytic profile is compared with the formerly defined antidepressant and neuroleptic profiles and can be clearly distinguished from the lat
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