Effect of Exogenous Prostaglandin E2on Plasma Antidiuretic Hormone in Normal Man
作者:
Mario Usberti,
Alba Gargiulo,
Enrico Comberti,
Salvatore Campisi,
Claudio Poiesi,
Mario Brognoli,
Cecilia Doregatti,
Mario Rondina,
Annibale Zaneboni,
Salvatore Ghielmi,
期刊:
American Journal of Nephrology
(Karger Available online 1989)
卷期:
Volume 9,
issue 4
页码: 285-290
ISSN:0250-8095
年代: 1989
DOI:10.1159/000167982
出版商: S. Karger AG
关键词: Endogenous angiotensin;Exogenous prostaglandin E2;Antidiuretic hormone
数据来源: Karger
摘要:
To verify if exogenous prostaglandin E2 (PGE2) is able to release antidiuretic hormone (ADH) and if endogenous angiotensin II plays a role in this eventual PGE2-induced stimulation of vasopressin, increasing doses of PGE2 were infused in 6 normal volunteers before (PGE2 study) and after the administration of 100 mg of captopril (captopril study). PGE2, even at an infusion rate of 40 and 60 ng/kg/min, did not modify blood pressure when it was infused alone; a significant fall of blood pressure was observed, in contrast, in the captopril study. PGE2 alone doubled the plasma levels of ADH. One hour after the subjects had been pre-treated with captopril, plasma levels of ADH fell by about 38%, then they increased by about 60% during the infusion of PGE2. These results suggest that in normal man endogenous angiotensin II is an important non-osmotic regulator of plasma ADH and that exogenous PGE2 can stimulate maximally the release of ADH only when the renin-angiotensin system is not impaired.
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