Is CA 242 Really a New Tumour Marker for Pancreatic Adenocarcinoma?
作者:
Mario Plebani,
Daniela Basso,
Filippo Navaglia,
Fiorella D’Angeli,
Maria Piera Panozzo,
Gerardo Del Giudice,
Marzia Battistel,
Tamara Meggiato,
Giuseppe Del Favero,
期刊:
Oncology
(Karger Available online 1995)
卷期:
Volume 52,
issue 1
页码: 19-23
ISSN:0030-2414
年代: 1995
DOI:10.1159/000227421
出版商: S. Karger AG
关键词: Pancreatic cancer;Gastric cancer;Colon cancer;CA242;CA 19-9
数据来源: Karger
摘要:
CA 242, a sialylated carbohydrate epitope situated on the same macromole-cule as CA 50 has been proposed as a new tumour marker for pancreatic cancer (PC). The aims of the present study were: (1) to evaluate serum CA 242 versus CA 19-9 in PC patients, and (2) to assess whether these markers can predict tumour spread or patient survival. We studied 59 healthy controls, 27 PC patients, 12 chronic pancreatitis cases, 107 with extra-pancreatic gastrointestinal tumours, 30 with benign jaundice and 24 with benign extra-pancreatic gastrointestinal diseases. Mean CA 242 values were significantly higher in PC than in any other group; CA 19-9 showed a similar pattern. The best diagnostic efficacy (ROC curves analysis) in diagnosing PC was 86% for CA 242 and 84% for CA 19-9, using cut-off values of 60 and 80 U/ml, respectively. In PC, serum levels of both markers were unrelated to tumour spread or size; in PC patients with high levels of CA 242 or CA 19-9 survival was significantly shorter. CA 242 and CA 19-9 were correlated both when considering all the patients together (r = 0.962, p < 0.001) and PC alone (r = 0.880, p < 0.001). Given the very close relationship between CA 242 and CA 19-9, we tested for cross-reactivity between CA 242 antigen and CA 19-9 antibody: CA 242 antigen with CA 19-9 antibody produced a similar curve to CA 242 antigen and its corresponding antibody. In conclusion, CA 242 showed similar diagnostic value to CA 19-9 in assessing PC patients; both seem unrelated to tumour size or spread, but seem to predict survival. Their remarkably similar behaviour is due to cross-reactivity between CA 242 antigen and CA 19-9 antibody, so CA 242 cannot, in our opinion, be considered a new tumour marker for PC.
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