Investigation of Exocrine Pancreatic Function by Continuous Infusion of Caerulein and Secretin in Normal Subjects and in Chronic Pancreatitis
作者:
L. Gullo,
P.L. Costa,
G. Fontana,
G. Labò,
期刊:
Digestion
(Karger Available online 1976)
卷期:
Volume 14,
issue 2
页码: 97-107
ISSN:0012-2823
年代: 1976
DOI:10.1159/000197914
出版商: S. Karger AG
关键词: Bicarbonates;Caerulein;Cholecystokinin;Chymotrypsin;Lipase;Pancreatic secretion;Pancreatitis;Secretin;Trypsin
数据来源: Karger
摘要:
Exocrine pancreatic function has been evaluated in 24 controls and 29 patients with confirmed chronic pancreatitis by continuous infusion (90 min) of synthetic caerulein, 100 ng/kg/h, plus GIH secretin, 1 CU/kg/h. Mean secretory values of the controls were comparable to those obtained by others using maximal doses of secretin and CCK. Unlike the controls, patients suffering from chronic pancreatitis demonstrated a progressive reduction in secretion during infusion. Thus, the comparison of responses for the final 30-min period gave much clearer and more complete discrimination between normal and abnormal pancreatic function than the preceding 30-min period.
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