MHC Restricted Recognition by Cloned T Cells
作者:
HodesRichard J.,
期刊:
International Reviews of Immunology
(Taylor Available online 1986)
卷期:
Volume 1,
issue 2
页码: 107-149
ISSN:0883-0185
年代: 1986
DOI:10.3109/08830188609056604
出版商: Taylor&Francis
数据来源: Taylor
摘要:
The critical role of major histocompatibility complex (MHC) gene products in T cell activation was appreciated and extensively studied well before the availability of monoclonal T cell populations. However, the availability of cloned T cells has dramatically enhanced the ability to characterize the nature of MHC-restricted recognition by T cells. In certain areas, the use of monoclonal T cells has allowed substantial extension of principles already established through the use of heterogeneous T cells. In other cases, studies employing T cell clones have led to findings which were inaccessible to approaches using only heterogeneous T cell populations. On balance, it should also be pointed out that a significant number of critical questions concerning the MHC-restricted T cell repertoire remain best approached by studying the development of interactions of functionally heterogeneous T cell populations. The present review will focus upon recent progress in several areas in which the use of cloned T cells has been particularly important in characterizing the nature of MHC-restricted recognition. In particular, the restriction of T cell recognition by class II MHC products (Ia) is examined in detail.
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