Eleven patients with upper gastrointestinal problems and normal upper gastrointestinal roentgenograms were found to have hemorrhagic duodenitis unassociated with peptic ulcer disease. The total number of patients evaluated by fiberoptic esophagogastroduodenoscopy was 135, with a frequency of 12 per cent for hemorrhagic duodenitis. Alcohol, aspirin and other irritants may be contributory factors in some of these patients.