Toxicity of metal ions to alveolar macrophages
作者:
V. Castranova,
L. Bowman,
P. R. Miles,
M. J. Reasor,
期刊:
American Journal of Industrial Medicine
(WILEY Available online 1980)
卷期:
Volume 1,
issue 3‐4
页码: 349-357
ISSN:0271-3586
年代: 1980
DOI:10.1002/ajim.4700010311
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: toxicity;metals;alveolar macrophages;oxygen consumption;chemiluminescence
数据来源: WILEY
摘要:
AbstractSignificant concentrations of metals are found in the respirable particulate effluents associated with metallurgical smelters. In this investigation the effects of the metallic ions lead, cadmium, iron, mercury, aluminum, chromium, and nickel on various aspects of alveolar macrophage function were studied. The production of antibacterial substances (ie, reactive forms of oxygen) by these cells and oxygen consumption are very sensitive to the metals. Particle uptake displays moderate sensitivity, while lysosomal enzyme activity and membrane integrity are fairly resistant to metals. In addition, the effects of the organic solvents carbon tetrachloride, toluene, and xylene on alveolar macrophage function were tested. These solvents were found to inhibit oxygen consumption and the release of antibacterial substances while not greatly affecting membrane integrity. The results of these experiments indicate that some metals and some organic substances are toxic to alveolar macrophage function.
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