THE MITOTIC RESPONSE OF THYMUS‐DERIVED CELLS TO ANTIGENIC STIMULUS
作者:
A. Davies,
E. Leuchars,
V. Wallis,
P. Koller,
期刊:
Transplantation
(OVID Available online 1966)
卷期:
Volume 4,
issue 4
页码: 438-451
ISSN:0041-1337
年代: 1966
出版商: OVID
数据来源: OVID
摘要:
A single thymus lobe from a neonatal donor has the capacity to restore primary immunological competence to a thymectomized syngeneic radiation chimaera. If a cytologically marked thymus graft is used the fate of the introduced cells following antigenic stimulation may be studied. Thymus-derived cells can be found in the spleen and lymph-nodes of such mice and furthermore there is a transient but well-defined increase in the proportion of these cells dividing following an injection of sheep red blood cells or application of a skin homograft 30 days after irradiation and thymus grafting. It was found that an even greater proportion of thymus-derived cells divide in response to a second challenge with sheep cells. Similarly, a higher percentage of thymus-derived cells divide in the lymph-nodes draining a second skin homograft.
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