Effect of Hemodialysis on Serum Concentrations of HPLC-Analyzed Accumulating Solutes in Uremia
作者:
A.C. Schoots,
J.A.G. Peeters,
P.G.G. Gerlag,
期刊:
Nephron
(Karger Available online 1989)
卷期:
Volume 53,
issue 3
页码: 208-217
ISSN:1660-8151
年代: 1989
DOI:10.1159/000185746
出版商: S. Karger AG
关键词: Uremic toxins;Dialysis ratio;Protein binding;Dialyzer clearance;Mass transfer coefficient;Hippurates;High-pressure liquid chromatography;Compartmentalization;Tubular secretion;Continuous ambulatory peritoneal dialysis
数据来源: Karger
摘要:
The concentration changes, during hemodialysis treatment, of 18 characteristic uremia compounds, analyzed by high-pressure liquid chromatography in sera of renal patients were studied. Pre- to postdialysis concentration ratios (dialysis ratio, D) varied from 0.83 to 3.04 for the different solutes. A division into three solute groups, on the basis of their D values, could be rationalized qualitatively from data on protein binding and dialyzer clearance. One group showed low dialysis ratios which could be explained from plasma protein binding. The second group had intermediate D values, comparable to those of creatinine. For some of the members of the third group, high D values might indicate a compartmentalization and resistance to mass transfer across biological membranes. Among the latter are the tubularly secreted hippuric acid and p-hydroxyhippuric acid. For most of the (protein-bound) solutes, protein binding was shown to decrease during hemodialysis. Protein binding levels were higher after dialysis only for hippuric acid and the as yet unidentified fluorescent solute designated UFK8. In conclusion, the change of serum concentrations and of protein binding resulting from hemodialysis treatment are presented and are compared for 18 accumulating solutes in sera of patients with end-stage renal failure.
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