Antimycobacterial Activity of Isoniazid + Prothionamide + Dapsone against a Number of Randomly Selected ‘Wild’ Strains ofMycobacterium tuberculosis
作者:
R. Urbanczik,
期刊:
Chemotherapy
(Karger Available online 1980)
卷期:
Volume 26,
issue 4
页码: 276-281
ISSN:0009-3157
年代: 1980
DOI:10.1159/000237917
出版商: S. Karger AG
关键词: Isoniazid;Prothionamide;Dapsone;Synergyin vitro;Dimethyl sulphoxide
数据来源: Karger
摘要:
46 strains of Mycobacterium tuberculosis were studied as to their susceptibility to isoniazid (INH) or to INH + prothionamide (PTH) in the presence or absence of dapsone (DDS) by microdilution transfer plate technique. Synergy with DDS as defined by Berenbaum in 1978 was seen in 78% with INH and in 91% with INH + PTH. It concerned the minimal inhibitory concentration, whereas the minimal bactericidal concentration (MBC) was unaffected in the case of INH and it was increased in only 52% with INH + PTH. The latter MBC proportion mentioned would be decreased to roughly 16% accepting an only twofold decrease in the MBC as possibly due to dilution errors. The possible effect of dimethyl sulphoxide on the reported results is discussed.
点击下载:
PDF
(1785KB)
返 回