This paper presents a method for developing occupational medical examinations using the preplacement examination (PPE) and the periodic monitoring examination (PME). The steps for developing an appropriate PPE include goal definition, analysis of job requirements and potential exposures, an occupational and medical history, and a targeted physical examination derived from the preceding steps. The PPE should result in the proper placement of the worker. It also serves as a baseline for comparison to future testing or health-related developments. The PME checks the effectiveness of more primary preventive measures such as plant engineering controls and personal protection. The contents and frequency of the PME depend on the pathophysiology and toxicology of the hazardous exposures, the interval exposure and medical history, and legal requirements. Individual and group results should be assessed periodically for trends suggesting work-related problems that would need further evaluation.