Appearance of Gastrin and Somatostatin in the Human Fetal Stomach, Duodenum and Pancreas
作者:
N.S. Track,
C. Creutzfeldt,
J. Litzenberger,
C. Neuhoff,
R. Arnold,
W. Creutzfeldt,
期刊:
Digestion
(Karger Available online 1979)
卷期:
Volume 19,
issue 5
页码: 292-306
ISSN:0012-2823
年代: 1979
DOI:10.1159/000198374
出版商: S. Karger AG
关键词: Radioimmunoassay;Ultrastructure;D cell;Gastrin;G cell;Human fetus;Immunohistochemistry
数据来源: Karger
摘要:
The gestational time of appearance of gastrin and somatostatin in the human fetal stomach, duodenum and pancreas was examined. Immunoreactive gastrin (IRG) is detected in antral, duodenal and pancreatic extracts of a 7.0-cm (crown-heel length) fetus. More IRG is extracted from the duodenum than the antrum. Duodenal IRG concentrations from fetuses of 16.0–26.0 cm are higher than younger fetal and adult concentrations. Antral IRG concentrations are one tenth of the adult contents. Very small IRG concentrations are present in the human fetal pancreas. Gastrin immunohistochemical staining is positive first in duodenal (6.5-cm fetus) and later in antral (12.5-cm fetus) mucosa; pancreatic tissue is negative for gastrin immunohistochemistry. Type IV cells are encountered in antral and duodenal mucosa of 4.0-cm fetuses; other endocrine cells appear with fetal growth. Not until much later in gestation (21.0 cm) do typical G cells appear. These results suggest that early in fetal life gastrin is produced by the type IV cell. Somatostatin immunohistochemical staining is positive in stomach, duodenum and pancreas in 6.5-cm fetuses. Immature D cells are found in antral and duodenal mucosa of 5.0-cm fetuses and mature D cells in 11.0-cm fetuse
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