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Cancer-Associated Lactate Dehydrogenase is a Tyrosylphosphorylated Form of Human LDH-A, Skeletal Muscle Isoenzyme

 

作者: L.Steven S.,   Ching E.Yu,   ShariefFarida S.,   Jo EvansMary,   FongMing,   ClintonGail M.,   HolbrookJ. John,  

 

期刊: Cancer Investigation  （Taylor Available online 1988）
卷期: Volume 6, issue 1  

页码: 93-101

 

ISSN:0735-7907

 

年代: 1988

 

DOI:10.3109/07357908809077032

 

出版商: Taylor&Francis

 

数据来源: Taylor

 

摘要:

AbstractCancer-associated lactate dehydrogenase is a tyrosylphosphorylated form of human skeletal muscle isoenzyme, since the partial amino acid sequences of human liver LDH-K/A protein were found to be identical with the known primary structure of human LDH-A isoenzyme and the LDH-A isoenzymes from human placenta and bovine muscle were shown to be tyrosylphosphorylated. This tyrosylphosphorylated LDH-K/A protein was also found to be complexed with 21 kD, 30 kD, and 56 kD proteins.

 

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