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A Qualitative and Quantitative Light Microscopic Study of the Inferior Olivary Complex in the Adult Staggerer Mutant Mouse

 

作者: BlattGene J.,   EisenmanLeonard M.,  

 

期刊: Journal of Neurogenetics  (Taylor Available online 1985)
卷期: Volume 2, issue 1  

页码: 51-66

 

ISSN:0167-7063

 

年代: 1985

 

DOI:10.3109/01677068509100143

 

出版商: Taylor&Francis

 

关键词: Key words:cerebellar mutants;inferior olive;staggerer

 

数据来源: Taylor

 

摘要:

In the homozygous staggerer(sg/sg)mutant mouse, most of the Purkinje cells (the primary targets for olivocerebellar climbing fibers) are missing or ectopic. In this study, the organization and cell number of the inferior olivary complex insg/sgwere determined and compared to the inferior olive of the wildtype (+ / +) mouse. Our results indicate that there is a marked disorganization and loss of almost 60% of the cells within the inferior olivary complex. This suggests that the inferior olive may be secondarily affected by the staggerer gene due to the defects in its main target cell, the Purkinje cell.

 

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