Prolonged postoral contraceptive amenorrhea in 41 women did not correlate with physical status, other endocrine abnormality or duration of pill therapy but did correlate with past menstrual dysfunction and/or absence of withdrawal bleeding during pill use. Duration of oral contraception did not correlate with length of amenorrhea or therapeutic response. Six patients had galactorrhea; while this probably does not alter prognosis, patients should be observed for a pituitary lesion. Menses resumed in 69% of the untreated women, 69% of the women treated with clomiphene and 42% after other agents. Patients with low serum LH and low total urinary estrogen levels responded poorly to clomiphene. A crude incidence of postpill amenorrhea of 2.2 per 1000 was noted among almost 20,000 oral contraceptive users.