Relationship between in vitro tumor stem cell assay and in vivo antitumor activity using the p388 leukemia
作者:
John C. Marsh,
Robert H. Shoemaker,
David H. Kern,
John M. Venditti,
期刊:
The International Journal of Cell Cloning
(WILEY Available online 1988)
卷期:
Volume 6,
issue 1
页码: 60-68
ISSN:0737-1454
年代: 1988
DOI:10.1002/stem.5530060107
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: Tumor cloning;In vitro‐in vivo correlation;Chemotherapy;P388 leukemia
数据来源: WILEY
摘要:
AbstractThe relationship between in vitro tumor stem cell sensitivity and in vivo antitumor efficacy using 13 active antineoplastic agents was examined by means of the intraperitoneal P388 mouse leukemia system. The doses, which produced a 50% increase in life span after one, five and nine days of treatment, were all significantly correlated with the in vitro concentration producing a 70% reduction in colony formation during a seven‐day continuous drug exposure. The five‐day correlation was the best, followed by nine days and one day. Correlations were not improved by corrections for either in vitro drug stability or toxicity (LD50). The highly significant correlations observed in this simple retrospective analysis provide a basis for the development of more sophisticated models for the prediction of in vivo results from in vitro d
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