Energy Sources for Contraction of the Rat Ventricle in Phosphate Media
作者:
David Berman,
Paul Saunders,
期刊:
Circulation Research
(OVID Available online 1955)
卷期:
Volume 3,
issue 6
页码: 559-563
ISSN:0009-7330
年代: 1955
出版商: OVID
数据来源: OVID
摘要:
Various substrates were tested for their ability to restore the amplitude of contraction of hypodynamic electrically-stimulated rat ventricle strips suspended in a phosphate-buffered medium. Greatest recovery of the contractile activity was obtained with pyruvate; lactate, β-hydroxybutyrate and acetate were more effective than succinate and glucose. The finding that glucose, in contrast to pyruvate, was relatively ineffective as an energy source for contraction, when a phosphate-buffered medium was employed, suggests that the defect was due to a rate-limiting step in the conversion of glucose to pyruvate, rather than to an impairment in the functioning of the Krebs cycle.
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