Mixtures of Toxic Agents and Attributable Risk Calculations
作者:
Fritz A. Seiler,
Bobby R. Scott,
期刊:
Risk Analysis
(WILEY Available online 1987)
卷期:
Volume 7,
issue 1
页码: 81-90
ISSN:0272-4332
年代: 1987
DOI:10.1111/j.1539-6924.1987.tb00971.x
出版商: Blackwell Publishing Ltd
关键词: attributable risks;probability of causation;assigned shares;synergistic interactions;uncertainty
数据来源: WILEY
摘要:
Calculations of attributable risks have attracted increasing interest recently. However, these efforts have been limited to mostly one agent, radiation, and no interactions with effects of other toxic agents have been taken into account. This paper outlines a generic approach to the calculation of attributable risks for an exposure to several toxic agents and interaction effects associated with them. In this calculation, the partition of interaction terms between the agents responsible is of particular importance. At present, there are no rules on how to assign equitable shares, so one methodology will be proposed and others discussed briefly. For one example of an assignment, the standard errors of the attributable risks are determined in terms of the uncertainties of the input parameters, thus setting the stage for a comparison of the different shares of responsibility.
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