Effect of an Aromatase Inhibitor in Human Follicular Fluid on DNA Synthesis of Granulosa Cells, Theca Cells, and Follicles
作者:
Tsutomu Ono,
Yu-Ichi Komiya,
Shin-Nosuke Kawagoe,
Masahiko Hiroi,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1993)
卷期:
Volume 35,
issue 3
页码: 169-171
ISSN:0378-7346
年代: 1993
DOI:10.1159/000292692
出版商: S. Karger AG
关键词: Aromatase inhibitor;Follicular fluid;Follicular maturation
数据来源: Karger
摘要:
An aromatase inhibitor was identified in human follicular fluid. We sought to examine the effects of this inhibitor on granulosa cells, theca cells, a mixture of granulosa and theca cells, and follicles. Granulosa cells, theca cells, the mixture of granulosa and theca cells, and follicles were incubated with [3H]-thymidine and aromatase inhibitor at 37°C for 40 h in Ham F-10 medium. The radioactivities of acid-insoluble fractions were counted. Aromatase inhibitor markedly inhibited the DNA synthesis of granulosa cells and follicles, but it did not inhibit the mixture of granulosa and theca cells. This suggested that aromatase inhibitor was a factor in the follicle paracrine system and acted mainly on granulosa cells
点击下载:
PDF
(1169KB)
返 回