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Altered Serum Lipoproteins and Apolipoproteins in Carotid Atherosclerosis

 

作者: Satoshi Kataoka,   Tsukasa Saigan,   Hidenobu Michishita,   Ariyuki Hori,   Genjiro Hirose,  

 

期刊: Cerebrovascular Diseases  (Karger Available online 1996)
卷期: Volume 6, issue 1  

页码: 21-27

 

ISSN:1015-9770

 

年代: 1996

 

DOI:10.1159/000107988

 

出版商: S. Karger AG

 

关键词: Atherosclerosis;Carotid atherosclerosis;Lipoprotein;Apolipoprotein;Risk factors in atherosclerosis

 

数据来源: Karger

 

摘要:

We evaluated the serum levels of lipoproteins and apolipoproteins in patients with angiographically proven extracranial and/or intracranial carotid atherosclerosis (ECA and/or ICA). The prevalence of hypertension, diabetes mellitus and smoking was significantly higher in patients with carotid atherosclerosis. Total HDL-cholesterol, HDL2-cholesterol and HDL3-cholesterol were higher in patients with carotid atherosclerosis than in patients without carotid atherosclerosis. The serum concentration of apolipoprotein A-I and A-II were significantly low in patients with ICA alone, ECA + ICA, bilateral carotid stenosis, and unilateral carotid occlusion. These data suggested that decreased serum HDL cholesterol and apolipoprotein A-I are potential indicators of the progression of carotid atherosclerosis in association with hypertension, diabetes mellitus and cigarette smoking.

 

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