Platelet‐associated immunoproteins (PAIg): specificity of measurement
作者:
P. HAN,
R. KIRUBA,
Y. C. HO,
期刊:
Clinical&Laboratory Haematology
(WILEY Available online 1990)
卷期:
Volume 12,
issue 1
页码: 49-56
ISSN:0141-9854
年代: 1990
DOI:10.1111/j.1365-2257.1990.tb01110.x
出版商: Blackwell Publishing Ltd
关键词: PAIg;specificity of measurement
数据来源: WILEY
摘要:
SummaryPlatelet‐associated Ig (PAIg) is raised in patients with idiopathic thrombocytopenic purpura. However, it is also raised in conditions not traditionally considered to be immune mediated. The latter finding suggests that raised PAIg may be an epiphenomenon of thrombocytopenia. The assays currently available do not distinguish between PAIg present due to a specific Fab binding or present due to non‐specific binding of Ig via Fc or complement receptors. In this paper we show that by prior incubation with normal rabbit serum, an assay for PAIg can be made specific for Fab bind
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