Is pure red cell aplasia (PRCA) a clonal disorder?
作者:
M. SIVAKUMARAN,
M. BHAVNANI,
A. STEWART,
B. E. ROBERTS,
G. C. GEARY,
期刊:
Clinical&Laboratory Haematology
(WILEY Available online 1993)
卷期:
Volume 15,
issue 1
页码: 1-5
ISSN:0141-9854
年代: 1993
DOI:10.1111/j.1365-2257.1993.tb00115.x
出版商: Blackwell Publishing Ltd
关键词: pure red cell aplasia;T‐cell receptor gene rearrangement;clonal T‐cell proliferations
数据来源: WILEY
摘要:
SummaryPure red cell aplasia (PRCA) is an uncommon disorder, many cases lacking a well defined aetiology. This report describes three cases of PRCA (two idiopathic and one associated with B‐CLL) who were investigated to assess the possibility of their PRCA being associated with a clonal proliferation of T‐lymphocytes. The results show that one patient had evidence of T‐cell receptor (TCR) gamma chain rearrangement, and the other had a TCR delta chain rearrangement. These two cases raise the possibility of PRCA being associated with a clonal proliferation of T‐cells and further studies are wa
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