AbstractMusizin, physcon, emodin and frangulin‐A have been isolated from the whole plant ofRhamnus procumbensand their structures established by a detailed study of spectral data and also by degradation methods. Pharmacological investigations on emodin have indicated that it possesses intestinal and cardiac stimulant, CNS depressant and analgesic activities. Such activities have not earlier been reported for emodin. This is also the first report of the isolation of these chemical constituents inRhamnus procumbensfand the second natural occurrence of musizi