Maternal and Cord Serum Levels of Tissue Polypeptide Antigen (TPA) in Normal Pregnancies
作者:
K. Bremme,
P. Eneroth,
B. Nilsson,
M. Olsson,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1985)
卷期:
Volume 19,
issue 3
页码: 118-123
ISSN:0378-7346
年代: 1985
DOI:10.1159/000299020
出版商: S. Karger AG
关键词: Tumor antigen;Tissue polypeptide antigen;Pregnancy;Cord
数据来源: Karger
摘要:
The tumor antigen and cytoskeleton protein tissue polypeptide antigen (TPA) have been determined in maternal serum throughout pregnancy. TPA levels in serum from pregnant women (n = 70) were not different from those in nonpregnant women (n = 61) until pregnancy week 28, from which time levels increased until parturition. Duplex pregnancies (n = 7) had higher serum TPA concentrations than simplex pregnancies, which was significant in pregnancy weeks 28 (p < 0.014) and 32 (p = 0.05). Maternal serum TPA concentrations did not change during abortion or parturition and the mixed umbilical blood concentration of TPA equaled that in the mother’s serum just after parturition. The correlation between placenta weight and maternal serum TPA levels was significant (p = 0.025). The decline of TPA after labor indicated a t½ for serum TPA of 7.5 days.
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