Quantitative Monoclonal Antibody Determination of Estrogen and Progesterone Receptors in Human Breast Cancer: Correlation with the Radioligand Method
作者:
F. Jarque,
A. Lluch,
E. Vizcarra,
M. Muñoz,
V. Alberola,
J.G. Garciá-Conde,
期刊:
Oncology
(Karger Available online 1994)
卷期:
Volume 51,
issue 5
页码: 435-439
ISSN:0030-2414
年代: 1994
DOI:10.1159/000227379
出版商: S. Karger AG
关键词: Enzyme immunoassay;Estrogen receptor;Progesterone receptor;Radioligand assay
数据来源: Karger
摘要:
To assess the possibility of substituting our routine method (dextran-coated charcoal, DCC) of determining estrogen (ER) and progesterone receptors (PR) for an enzyme immunoassay technique (EIA), we compared the two methods for determination of the two types of receptor in breast cancer specimens. In terms of sample positivity or negativity, the two techniques agreed in 76 of the 82 samples analyzed for ER (92.7%; p < 0.001), and in 65 out of 75 samples assayed for PR (86.6%; p < 0.001). Quantitative analysis of the data showed a significant correlation between DCC and EIA for both ER (r = 0.84; p < 0.0001) and PR (r = 0.77; p < 0.0001). The results suggest the usefulness of EIA in substituting DCC, although further clinical studies are required to fully evaluate this new method.
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