AbstractThe hypoglycaemic effect ofAnthocleista vogeliiwas studied in mice, rats and rabbits. Aqueous extract of the plant obtained by infusion from finely pulverized root was used. The extract (100, 400 and 800 mg/kg) induced significant hypoglycaemic activity in a dose‐related fashion at 2 h after oral administration in mice and rats with ED25of 250 mg/kg and 350 mg/kg respectively. The extract (800 mg/kg, orally) similarly induced statistically significant lowering of blood glucose levels at 8 h in normoglycaemic rabbits. The extract (400 mg/kg and 800 mg/kg, orally) also caused reduction of blood glucose levels in alloxan‐induced diabetic animals. The results of this study indicate that the aqueous extract of the roots ofAnthocleista vogeliipossess favourable hypoglycaemic activity both in normo and hyperglycaemic animals compared to chlorpropamide as a stand