Local Hemostasis in Subarachnoid Hemorrhage
作者:
F.J. von Baumgarten,
G. Burkhard,
D. Englert,
P. Kraus,
H.G. Mertens,
G. Müller-Berghaus,
H. Przuntek,
期刊:
European Neurology
(Karger Available online 1987)
卷期:
Volume 27,
issue 3
页码: 149-154
ISSN:0014-3022
年代: 1987
DOI:10.1159/000116148
出版商: S. Karger AG
关键词: Subarachnoid hemorrhage;Vasospasm;Antifibrinolytic treatment;Fibrinopeptide A;Platelet-secreted protein;Cerebrospinal fluid
数据来源: Karger
摘要:
Fibrinopeptide A (FPA), platelet-secreted protein, platelet factor 4 and beta-thromboglobulin were determined in the cerebrospinal fluid of patients who had suffered from subarachnoid hemorrhage and were treated with 6 g tranexamic acid or 4 million KIU aprotinin to prevent rebleeding. Platelet-secreted proteins and FPA were cleared from the cerebrospinal fluid within 3 days after bleeding. Their vasoactive and thrombotic capability is limited to the initiation period of vasospasm that usually comes to clinical observation 3–8 days after bleeding. Increased thrombotic activity of the cerebrospinal fluid, as reflected by high levels of FPA and platelet-secreted protein, seemed to promote the occurrence of neurological deficit
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