AbstractIntense research efforts have been directed toward characterizing mediators that control the inflammatory response and regulate the growth, differentiation, and function of cells involved in inflammation. Tumor necrosis factor, or cachectin, and members of a heterogeneous group of peptides called interleukins exhibit a wide spectrum of activities, some of which appear to influence the evolution of inflammatory processes. This review outlines the observations that have led to our current understanding of the biology of tumor necrosis factor and the interleukins. Particular attention is directed toward the evidence suggesting that these cytokines function as mediators of inflammatory responses.